Start from the beginning.
-How long has the system been established?
-When was the first fish added?
-When was the last fish added?
-How long (if any) did you quarantine your fishes?
-What species of fishes and what sizes?
-Which fish was the first to catch ich?
-Did all the fishes come from the same source?
-Feeding and maintainence routine?
-Checked for stray current?
Ich is not just a magic bug that pops up for no reason, there is usually a cause, be it sick fish bringing it in, stress, water qulity, stray current, malnutrition, etc. Kinda like the "common cold" in people.
There are numerous additives I think Ruby Reef Rally being the "most reef safe."
You can also supplement their food to aid in resistance and healing.
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