Totally. You can successfully run any sized tank, and you don't really even need hob filters. It would require weekly water changes instead of monthly.
Yes and you can even mod the aquaclear 110 into a fuge pretty easy. I am just starting a 37 gallon with a hob filter, I thought about a skimmer but decided I would just do weekly water changes. Softies and lps in the tank will work well since they like dirty water compared to sps.
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